Chanarin I, Samson D, Lang A, Casey R, Lorkin P A, Lehmann H
Br J Haematol. 1975 Jun;30(2):167-75. doi: 10.1111/j.1365-2141.1975.tb00531.x.
A 63-year-old man with erythraemia was found to have a high affinity haemoglobin which was subsequently identified as Hb San Diego beta 109 (G11) Val leads to Met, recently described in a Filipino family (Nute et al, 1974). The oxygen affinity of the haemolysates was increased approximately two-fold at pH values between 6.04 and 7.90. The n value was nearly normal (2.5-2.9) in the upper range of saturation (70-95% oxygenation) but was somewhat diminished (1.9-2.1) below this range. In vitro biosynthesis of globin by reticulocytes showed that there was balanced synthesis of alpha and beta chains (alpha:beta ratio = 1).
一名患有红细胞增多症的63岁男性被发现有一种高亲和力血红蛋白，随后被鉴定为Hb圣地亚哥β109（G11）缬氨酸突变为甲硫氨酸，这是最近在一个菲律宾家庭中描述的（努特等人，1974年）。在pH值6.04至7.90之间，溶血产物的氧亲和力增加了约两倍。在饱和度较高的范围（70%-95%氧合）内，n值接近正常（2.5-2.9），但在该范围以下有所降低（1.9-2.1）。网织红细胞对珠蛋白的体外生物合成表明，α链和β链的合成是平衡的（α:β比率=1）。
