N-乙酰基转移酶2单核苷酸多态性与胃癌风险

N-acetyltransferase 2 single-nucleotide polymorphisms and risk of gastric carcinoma.

作者信息

Ladero José M, Agúndez José A G, Olivera Manuela, Lozano Luis, Rodríguez-Lescure Alvaro, Diaz-Rubio Manuel, Benítez Julio

机构信息

Gastroenterology Service, Hospital Clínico San Carlos, Medical School, Universidad Complutense, Madrid, Spain.

出版信息

Eur J Clin Pharmacol. 2002 May;58(2):115-8. doi: 10.1007/s00228-002-0460-7. Epub 2002 Apr 17.

DOI:10.1007/s00228-002-0460-7

PMID:12012143

Abstract

OBJECTIVE

To explore whether an association exists between the NAT2 genotype and the risk of developing gastric cancer.METHODS. Ninety-nine patients with gastric adenocarcinoma and 258 healthy subjects were analysed for single-nucleotide polymorphisms at the NAT2 gene locus, which give rise to gene variants known to be associated with slow-acetylation status.

RESULTS

The functional NAT2*4 (wild-type) allele is over-represented among patients (40.4% of all allelic variants) compared with control subjects [25.8%, odds ratio (OR) 1.95, 95% confidence interval (CI) 1.36, 2.8]. According to the NAT2 genotype, 69 patients (69.9%) and 119 healthy subjects (46%) were classified as rapid acetylators (OR 2.69, 95% CI 1.6, 4.54).

CONCLUSIONS

Our results, which need independent confirmation, suggest that individuals with NAT2 genotypes leading to high levels of NAT2 enzyme activity are at increased risk of developing gastric carcinoma.

摘要

目的

探讨NAT2基因分型与患胃癌风险之间是否存在关联。方法：对99例胃腺癌患者和258名健康受试者的NAT2基因位点进行单核苷酸多态性分析，该基因位点产生的基因变异与慢乙酰化状态相关。结果：与对照组相比，功能性NAT2*4（野生型）等位基因在患者中所占比例过高（占所有等位基因变异的40.4%），对照组为25.8%，优势比（OR）为1.95，95%置信区间（CI）为1.36至2.8。根据NAT2基因分型，69例患者（69.9%）和119名健康受试者（46%）被归类为快速乙酰化者（OR为2.69，95%CI为1.6至4.54）。结论：我们的结果需要独立验证，结果表明，具有导致NAT2酶活性水平较高的NAT2基因分型的个体患胃癌的风险增加。