阿曼胃癌患者的NAT2基因多态性——风险易感性及临床病理关联
NAT2 polymorphism in Omani gastric cancer patients-risk predisposition and clinicopathological associations.
作者信息
Al-Moundhri Mansour S, Al-Kindi Mohamed, Al-Nabhani Maryam, Al-Bahrani Bassim, Burney Ikram A, Al-Madhani Ali, Ganguly Shyam S, Tanira Misbah
机构信息
Department of Medicine, College of Medicine and Health Sciences, Sultan Qaboos University, PO Box 35, postal code 123, Muscat, Sultanate of Oman.
出版信息
World J Gastroenterol. 2007 May 21;13(19):2697-702. doi: 10.3748/wjg.v13.i19.2697.
AIM
To study whether N-acetyltransferase 2 (NAT2) genotypes and phenotypes are associated with increased risk factor for gastric cancer in Omani patients and to study the clinico-pathological correlations and the prognostic significance of NAT2.
METHODS
Genomic DNA was extracted from peripheral blood of 100 gastric cancer patients and 100 control subjects. NAT2 genotyping was performed using DNA sequencing. The prognostic significance of NAT2 and other clinicopathological features was assessed by univariate and multivariate analyses.
RESULTS
We observed no significant association between NAT2 genotypes and phenotypes and gastric cancer risk. The NAT2 phenotype polymorphisms and gastric cancer risk predisposition were not modified by concomitant H pylori infection and smoking. There was no significant association between NAT2 and clinicopathological features, and NAT2 had no independent prognostic significance.
CONCLUSION
In the current study, NAT2 genotypes and phenotypes are not associated with gastric cancer risk predisposition. Moreover NAT2 phenotypes had no clinicopathological associations or prognostic significance.
目的
研究N-乙酰基转移酶2（NAT2）基因分型和表型是否与阿曼患者患胃癌的风险增加相关，并研究NAT2的临床病理相关性及预后意义。
方法
从100例胃癌患者和100例对照者的外周血中提取基因组DNA。采用DNA测序法进行NAT2基因分型。通过单因素和多因素分析评估NAT2及其他临床病理特征的预后意义。
结果
我们观察到NAT2基因分型和表型与胃癌风险之间无显著关联。NAT2表型多态性和胃癌风险易感性不会因合并幽门螺杆菌感染和吸烟而改变。NAT2与临床病理特征之间无显著关联，且NAT2无独立的预后意义。
结论
在本研究中，NAT2基因分型和表型与胃癌风险易感性无关。此外，NAT2表型与临床病理无关联，也无预后意义。
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