Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
Gastric Cancer. 2009;12(4):198-205. doi: 10.1007/s10120-009-0523-x. Epub 2010 Jan 5.
Although the associations between grilled (broiled) or barbecued meats or fish intake and stomach cancer risk have been investigated, the evidence implicating heterocyclic amine (HCA) intake as a cause of stomach cancer is limited. We conducted a case-control study to investigate the association between HCA intake and stomach cancer risk. We also investigated the possible effect of genetic polymorphisms of NAT2, CYP1A1, and CYP1A2 on stomach cancer.
HCA exposure data were assessed using a self-administered food-frequency questionnaire, and estimated HCA intake was verified by measuring 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) values in human hair. A total of 149 cases and 296 controls were included in the analyses. Odds ratios (ORs) were calculated, using conditional logistic regression analysis, to compare intake levels between the first and third tertiles.
Results showed no statistically significant increase in the risk of stomach cancer with respect to total HCA intake (OR, 1.11; 95% confidence interval [CI], 0.36, 3.49), or with respect to the intake of individual HCAs; namely, PhIP, 2-amino-3, 4-dimethylimidazo[4,5-f]quinoline (MeIQ), and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx). Genetic polymorphisms of NAT2, CYP1A1, and CYP1A2 did not influence the association of HCA intake with stomach cancer.
In the present study, with a limited sample size of subjects with low HCA exposure, no association was found between HCA intake and stomach cancer, nor was there any evidence of any influence by genetic polymorphisms of NAT2, CYP1A1, and CYP1A2 on the risk of stomach cancer.
尽管已经研究了烤（熏）肉类或鱼类摄入与胃癌风险之间的关联，但将杂环胺（HCA）摄入作为胃癌病因的证据有限。我们进行了一项病例对照研究，以调查 HCA 摄入与胃癌风险之间的关系。我们还研究了 NAT2、CYP1A1 和 CYP1A2 基因多态性对胃癌的可能影响。
使用自我管理的食物频率问卷评估 HCA 暴露数据，并通过测量人发中的 2-氨基-1-甲基-6-苯基咪唑[4,5-b]吡啶（PhIP）值来验证 HCA 摄入。共有 149 例病例和 296 例对照纳入分析。使用条件逻辑回归分析计算比值比（OR），以比较第一和第三 tertile 之间的摄入水平。
结果显示，总 HCA 摄入（OR，1.11；95%置信区间 [CI]，0.36，3.49）或个别 HCA 的摄入与胃癌风险之间没有统计学上的显著增加；即 PhIP、2-氨基-3,4-二甲基咪唑[4,5-f]喹啉（MeIQ）和 2-氨基-3,8-二甲基咪唑[4,5-f]喹喔啉（MeIQx）。NAT2、CYP1A1 和 CYP1A2 的基因多态性并不影响 HCA 摄入与胃癌之间的关联。
在本研究中，由于暴露于低 HCA 的受试者样本量有限，未发现 HCA 摄入与胃癌之间存在关联，也没有证据表明 NAT2、CYP1A1 和 CYP1A2 基因多态性对胃癌风险有任何影响。
