Morali A
Hôpital d'Enfants, CHU Nancy-Brabois, Allée du Morvan, 54500 Vandoeuvre-les-Nancy.
Allerg Immunol (Paris). 2002 Mar;34(3):100-2.
Coeliac disease is an intolerance to gluten that classically produces a chronic diarrhoea with a picture of malabsorption and a total villous atrophy. These elements regress completely in a sequential way under a prolonged strict gluten-free diet. The progress registered in the understanding of this affection depends on the individualization of the atypical forms (delayed isolated stature, constipation...) of asymptomatic forms thanks to the study of specific antibodies (anti-gliadin, anti-endomysium, and more recently anti-transglutaminase). The auto-immune nature of coeliac disease is well established. The diagnostic criteria are simplified allowing the commencement of a gluten-free diet which must be perfectly detailed. Finally, allergy to wheat flour merits individualization in the framework of coeliac disease (cf. article).
乳糜泻是一种对麸质不耐受的疾病,典型症状为慢性腹泻,并伴有吸收不良和全绒毛萎缩。在长期严格的无麸质饮食下,这些症状会依次完全消退。由于对特定抗体(抗麦醇溶蛋白、抗肌内膜,以及最近的抗转谷氨酰胺酶)的研究,在对这种疾病的认识上取得的进展取决于对无症状形式的非典型形式(身材发育迟缓、便秘等)进行个体化诊断。乳糜泻的自身免疫性质已得到充分证实。诊断标准得到简化,使得可以开始必须详细制定的无麸质饮食。最后,在乳糜泻的框架内,对面粉过敏值得个体化研究(参见文章)。