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[简化的霍奇金-赫胥黎模型中的兴奋传播速率。I. 钠电流的快速弛豫]

[Rate of excitation propagation in a reduced Hodgkins-Huxley model. I. Rapid relaxation of the sodium current].

作者信息

Pastushenko V F, Markin V S

出版信息

Biofizika. 1975 Jul-Aug;20(4):675-81.

PMID:1201303
Abstract

The question of calculating excitation propagation velocity is analyzed on the basis of the Hodgkin-Huxley model. The activation of the sodium current is assumed to be rapid as compared to the rate of potential variation. Because of slow variation of potassium activation and sodium inactivation the dynamics of these processes is assumed to be of negligible effect in the region of impulse velocity formation. By means of pieace-wise linear approximation of thus obtained voltage-current characteristics the characteristics the analytical solution of the problem was found. In two limiting cases this solution coincides with the solutions of Kolmogorov and Scott. The dependence of impulse velocity on parameters is analyzed and illustrated graphically.

摘要

基于霍奇金-赫胥黎模型对计算兴奋传播速度的问题进行了分析。假设钠电流的激活与电位变化速率相比是快速的。由于钾激活和钠失活的变化缓慢,在脉冲速度形成区域,这些过程的动力学被认为影响可忽略不计。通过对由此得到的电压-电流特性进行分段线性近似,找到了该问题的解析解。在两种极限情况下,该解与科尔莫戈罗夫和斯科特的解一致。分析了脉冲速度对参数的依赖性并以图形方式进行了说明。

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