Pastushenko V F, Chizmadzhev Iu A, Markin V S
Biofizika. 1975 Nov-Dec;20(6):1078-82.
The Hodgkin - Huxley system of equations is reduced to single integral-differential equation in neglection of slow variables dynamics. Two limiting cases of fast and slow sodium activation processes are considered. The first case leads to a nonlinear differential equation for the potential, the second one - to an ordinary differential equation with a known source as a function of coordinate. Such a simplification is due to approximation of steady-state sodium activation variable with the help of Heviside function. The validity of this approximation is discussed; the corresponding error is estimated by calculation of the second approximation for the source function.
在忽略慢变量动力学的情况下,霍奇金 - 赫胥黎方程组被简化为单个积分 - 微分方程。考虑了快速和慢速钠激活过程的两种极限情况。第一种情况导致了关于电位的非线性微分方程,第二种情况导致了一个以坐标函数为已知源的常微分方程。这种简化是由于借助海维赛德函数对稳态钠激活变量进行了近似。讨论了这种近似的有效性;通过计算源函数的二阶近似来估计相应的误差。