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[简化霍奇金-赫胥黎模型中的兴奋传播速率。III. 积分微分方程]

[Rate of excitation propagation in a reduced Hodgkins-Huxley model. III. Integrodifferential equations].

作者信息

Pastushenko V F, Chizmadzhev Iu A, Markin V S

出版信息

Biofizika. 1975 Nov-Dec;20(6):1078-82.

PMID:1203296
Abstract

The Hodgkin - Huxley system of equations is reduced to single integral-differential equation in neglection of slow variables dynamics. Two limiting cases of fast and slow sodium activation processes are considered. The first case leads to a nonlinear differential equation for the potential, the second one - to an ordinary differential equation with a known source as a function of coordinate. Such a simplification is due to approximation of steady-state sodium activation variable with the help of Heviside function. The validity of this approximation is discussed; the corresponding error is estimated by calculation of the second approximation for the source function.

摘要

在忽略慢变量动力学的情况下,霍奇金 - 赫胥黎方程组被简化为单个积分 - 微分方程。考虑了快速和慢速钠激活过程的两种极限情况。第一种情况导致了关于电位的非线性微分方程,第二种情况导致了一个以坐标函数为已知源的常微分方程。这种简化是由于借助海维赛德函数对稳态钠激活变量进行了近似。讨论了这种近似的有效性;通过计算源函数的二阶近似来估计相应的误差。

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