Linnebur Sunny A, Saseen Joseph J, Pace Wilson D
Department of Pharmacy Practice, School of Pharmacy, University of Colorado Health Sciences Center, Denver 80262, USA.
Pharmacotherapy. 2002 May;22(5):652-5. doi: 10.1592/phco.22.8.652.33219.
A 41-year-old amenorrheic woman started taking venlafaxine 37.5 mg/day for treatment of depression; 7 days later, she experienced vaginal bleeding, which ceased 1 day after she stopped taking the drug. On rechallenge with venlafaxine, she again experienced vaginal bleeding that resolved after discontinuation. We found no published reports describing vaginal bleeding associated with venlafaxine. However, premarketing and postmarketing data report similar adverse effects in patients taking the agent. In addition, several cases of menstrual irregularities have occurred with two other antidepressants: fluoxetine and bupropion. This case report supports previous surveillance data indicating that venlafaxine may cause vaginal bleeding.
一名41岁的闭经女性开始服用文拉法辛，剂量为每日37.5毫克，用于治疗抑郁症；7天后，她出现阴道出血，停药1天后出血停止。再次服用文拉法辛时，她又出现阴道出血，停药后出血症状消失。我们未找到已发表的描述文拉法辛相关阴道出血的报告。然而，上市前和上市后的数据报告显示，服用该药物的患者存在类似不良反应。此外，另外两种抗抑郁药氟西汀和安非他酮也出现了几例月经不调的情况。本病例报告支持了先前的监测数据，表明文拉法辛可能导致阴道出血。
