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文拉法辛与氟西汀治疗重度抑郁和 melancholia 住院患者的双盲对照研究。文拉法辛法国住院患者研究组。

A double-blind comparison of venlafaxine and fluoxetine in patients hospitalized for major depression and melancholia. The Venlafaxine French Inpatient Study Group.

作者信息

Clerc G E, Ruimy P, Verdeau-Pallès J

机构信息

Centre Hospitalier, Pontorson, France.

出版信息

Int Clin Psychopharmacol. 1994 Sep;9(3):139-43. doi: 10.1097/00004850-199409000-00001.

DOI:10.1097/00004850-199409000-00001
PMID:7814822
Abstract

The antidepressant efficacy and short-term safety of venlafaxine and fluoxetine were compared in 68 patients hospitalized with major depression and melancholia. Venlafaxine was superior in efficacy to fluoxetine; total scores for both the MADRS and the HAM-D were significantly (p < or = 0.05) lower in the venlafaxine group than in the fluoxetine group at Weeks 4 and 6. Overall tolerance was similar for the two treatments.

摘要

对68例因重度抑郁和 melancholia 住院的患者比较了文拉法辛和氟西汀的抗抑郁疗效及短期安全性。文拉法辛在疗效上优于氟西汀；在第4周和第6周时，文拉法辛组的MADRS和HAM-D总分显著（p≤0.05）低于氟西汀组。两种治疗的总体耐受性相似。

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