组胺及某些组胺样激动剂对猫血压的影响。
The effects of histamine and some histamine-like agonists on blood pressure in the cat.
作者信息
Owen D A
出版信息
Br J Pharmacol. 1975 Oct;55(2):173-9. doi: 10.1111/j.1476-5381.1975.tb07626.x.
Abstract
- The effects of histamine on blood pressure have been compared with the effects caused by four histamine-like agonists in anaesthetized cats. 2. It has been confirmed that the depressor responses to histamine involve both H1- and H2-receptors: depressor responses also follow the administration of selective H1- and H2-receptor agonists. 3. 2-Methylhistamine, in doses up to 1 X 10(-7) mol/kg, lowers blood pressure by interaction with H1-receptors. Larger doses of 2-methylhistamine also lower blood pressure but this may involve H2-receptors. 4. 4-Methylhistamine, in doses up to 1 X 10(-7) mol/kg, lowers blood pressure by interaction with H2-receptors. Larger doses of 4-methylhistamine also lower blood pressure but this may involve H1-receptors. 5. 2-(2-Aminoethyl)pyridine and 2-(2-aminoethyl)thiazole both lower blood pressure by interaction with H1-receptors only. 6. The potential value and limitations of these compounds as tools to investigate the cardiovascular effects of histamine are discussed.
摘要
- 已将组胺对血压的作用与四种组胺样激动剂在麻醉猫身上所产生的作用进行了比较。2. 已证实，对组胺的降压反应涉及H1和H2受体：给予选择性H1和H2受体激动剂后也会出现降压反应。3. 剂量高达1×10⁻⁷摩尔/千克的2-甲基组胺通过与H1受体相互作用降低血压。更大剂量的2-甲基组胺也会降低血压，但这可能涉及H2受体。4. 剂量高达1×10⁻⁷摩尔/千克的4-甲基组胺通过与H2受体相互作用降低血压。更大剂量的4-甲基组胺也会降低血压，但这可能涉及H1受体。5. 2-(2-氨基乙基)吡啶和2-(2-氨基乙基)噻唑均仅通过与H1受体相互作用来降低血压。6. 讨论了这些化合物作为研究组胺心血管作用工具的潜在价值和局限性。
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