组胺H2受体调节全身性过敏反应：组胺对犊牛心血管系统的双重作用
Histamine H2-receptors modulate systemic anaphylaxis: a dual cardiovascular action of histamine in calves.
作者信息
Eyre P, Wells P W
出版信息
Br J Pharmacol. 1973 Oct;49(2):364-7. doi: 10.1111/j.1476-5381.1973.tb08385.x.
Abstract
Depressor changes in carotid blood pressure caused by histamine or anaphylaxis in calves, were incompletely blocked by the H(1)-receptor antagonist mepyramine. Burimamide, the selective histamine H(2)-receptor antagonist, potentiated the depressor actions of histamine and anaphylaxis. Potentiated depressor responses were inhibited by mepyramine. Observations are consistent with histamine stimulating both H(1)- and H(2)-receptors to cause respectively vasodilatation and vasoconstriction.
摘要
组胺或过敏反应引起的犊牛颈动脉血压下降变化，未被H(1)受体拮抗剂美吡拉敏完全阻断。选择性组胺H(2)受体拮抗剂布立马胺增强了组胺和过敏反应的降压作用。增强的降压反应被美吡拉敏抑制。这些观察结果与组胺刺激H(1)和H(2)受体分别引起血管舒张和血管收缩一致。
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