Kamio Yumie, Nanbu Yuko, Futamata Hideo, Fujita Shinichi, Kobayashi Tsutomu, Fujimura Masaki
Department of Laboratory, Kanazawa University Hospital, Kanazawa 920-8641.
Rinsho Byori. 2002 Apr;50(4):410-4.
We have established a 15-seconds tidal breathing method using our originally developed apparatus to measure cough sensitivity to capsaicin. Astograph, an apparatus to measure bronchial responsiveness to methacholine, has been widely used in clinical practice in Japan. If Astograph is available for measurement of cough sensitivity, it will contribute to promoting the spread of cough sensitivity test.
Fifteen-seconds tidal breathing methods using our original apparatus and Astograph were compared in 29 healthy subjects. To assess the agreement of the two methods, increasing concentrations of capsaicin solution were inhaled for 15 seconds until 5 or more cough were elicited and cough threshold, the lowest concentration of capsaicin eliciting 5 or more coughs, was determined by each method on 2 separate days at one week interval. On each day, the cough threshold measurement was repeated twice at one-hour interval to assess the repeatability.
Difference and repeatability coefficient were 0.35 and 2.00 in our original method and 0.14 and 1.88 doubling concentration in Astograph method, respectively, indicating good repeatability of both methods. Difference and coefficient of agreement between the two methods was 0.30 and 2.44 doubling concentration, respectively.
Astograph is suitable for measurement of cough sensitivity to capsaicin because of its good repeatability and agreement with our original method already established.
我们使用自主研发的仪器建立了一种15秒潮气呼吸法，用于测量对辣椒素的咳嗽敏感性。Astograph是一种用于测量对乙酰甲胆碱支气管反应性的仪器，在日本临床实践中已被广泛使用。如果Astograph可用于测量咳嗽敏感性，将有助于推动咳嗽敏感性测试的普及。
在29名健康受试者中比较了使用我们的原始仪器和Astograph的15秒潮气呼吸法。为评估两种方法的一致性，吸入浓度递增的辣椒素溶液15秒，直至引发5次或更多次咳嗽，在间隔一周的2个不同日期，用每种方法确定引发5次或更多次咳嗽的辣椒素最低浓度即咳嗽阈值。每天，咳嗽阈值测量以1小时间隔重复两次以评估重复性。
我们原始方法的差异和重复性系数分别为0.35和2.00，Astograph方法的差异和重复性系数分别为0.14和1.88倍浓度，表明两种方法均具有良好的重复性。两种方法之间的差异和一致性系数分别为0.30和2.44倍浓度。
Astograph因其良好的重复性以及与我们已建立的原始方法的一致性，适用于测量对辣椒素的咳嗽敏感性。
