Vergouwen A C M, Bakker A
Sint Lucas Andreas Ziekenhuis, locatie Lucas, afd. Psychiatrie, Postbus 9243, 1006 AE Amsterdam.
Ned Tijdschr Geneeskd. 2002 Apr 27;146(17):811-2.
Two patients, a 29-year-old man and a 32-year-old woman who were being treated with paroxetine HCl hemihydrate for depression and panic disorder with agoraphobia, respectively, unexpectedly developed complaints after switching to paroxetine mesylate. The symptoms were generalised itching with relapse of the depressive disorder in the man, and nausea with diarrhoea in the woman. The symptoms disappeared after the original treatment with paroxetine HCl hemihydrate was resumed. In the first patient, a rechallenge with the mesylate form of paroxetine led to the same complaints which subsided again after using the first product. Those treating such patients, and the patients themselves, should be informed if the delivery form of paroxetine is changed.
两名患者，一名29岁男性和一名32岁女性，分别正在接受半水合盐酸帕罗西汀治疗抑郁症和伴有广场恐惧症的惊恐障碍，在换用甲磺酸帕罗西汀后意外出现不适。症状为男性全身瘙痒且抑郁症复发，女性恶心并伴有腹泻。恢复使用原来的半水合盐酸帕罗西汀治疗后症状消失。在第一名患者中，再次使用甲磺酸帕罗西汀导致相同的不适，在使用第一种产品后不适再次消退。如果帕罗西汀的剂型发生改变，应告知治疗此类患者的人员以及患者本人。
