Fraiture A L, Henry F, Goffin V, Piérard G E
Service de Dermatopathologie, Université de Liège.
Rev Med Liege. 2002 Mar;57(3):179-82.
There exists several clinical types of scleroderma. Most of them show cutaneous manifestations. Skin involvement may be isolated (morphea) or be part of a multi-organ systemic disease. Objective non-invasive functional methods are useful in order to better assess the severity and evolution of the disease and the effects of treatments. Measurements of the thickness and mechanical properties of the skin as well as the visualization of the cutaneous blood flow prove to be informative.
硬皮病有几种临床类型。其中大多数表现出皮肤症状。皮肤受累可能是孤立的（硬斑病），或者是多器官系统性疾病的一部分。客观的非侵入性功能方法有助于更好地评估疾病的严重程度和进展以及治疗效果。测量皮肤厚度和力学性能以及观察皮肤血流情况都很有意义。
