AvRuskin Theodore W, Juan Christina S
Department of Pediatrics, The Brookdale University Hospital and Medical Center, State University of New York at Brooklyn, 11212-3198, USA.
J Pediatr Endocrinol Metab. 2002 May;15(5):629-36. doi: 10.1515/jpem.2002.15.5.629.
A 30year-old Hispanic male who presented with transient neonatal diabetes mellitus at 4 months has been intensively studied with 12 islet-cell secretagogues from 4 months to 24 years. He was both ICA- and GAD-65-negative, but at 28 years was diagnosed with hypothyroidism due to positive thyroperoxidase antibodies. The course of his disease(s) and the various presentations of hyperglycemia are documented and illustrated by the responses in islet cell hormone secretion, namely, insulin, glucagon, and C-peptide. Insulin secretion gradually fell over 24 years, glucagon secretion persisted from infancy to 24 years but was only minimal during i.v. glucose at 24 years, and C-peptide secretion remained normal, although modest, throughout the 24 years. These data suggest that, despite changing presentations of diabetes mellitus over time, the islets continued to process proinsulin, although the patient required insulin therapy.
一名30岁的西班牙裔男性，4个月时出现短暂性新生儿糖尿病，从4个月到24岁期间，使用12种胰岛细胞促分泌剂对其进行了深入研究。他的胰岛细胞抗体（ICA）和谷氨酸脱羧酶65（GAD-65）均为阴性，但在28岁时，因甲状腺过氧化物酶抗体呈阳性而被诊断为甲状腺功能减退。通过胰岛细胞激素分泌（即胰岛素、胰高血糖素和C肽）的反应记录并说明了他的病程以及高血糖的各种表现。胰岛素分泌在24年中逐渐下降，胰高血糖素分泌从婴儿期到24岁一直存在，但在24岁时静脉注射葡萄糖期间仅处于最低水平，而C肽分泌在整个24年中一直保持正常，尽管水平不高。这些数据表明，尽管随着时间的推移糖尿病的表现有所变化，但胰岛仍继续处理胰岛素原，尽管该患者需要胰岛素治疗。
