Knill R L, Evans D
Can Anaesth Soc J. 1975 Nov;22(6):637-46. doi: 10.1007/BF03013310.
We have demonstrated the toxicity of diazepam and the safety of ketamine hydrochloride following intra-arterial injection in an anaesthetized animal model. The pathogenesis of gangrene following intra-arterial injection of drugs is unclear. Clinical reports and this experiment suggest that it only follows injection of highly membrane-soluble drugs. Early swelling and disruption of capillary endothelial cells were demonstrated after intra-arterial injection of diazepam and thiopentone. We believe that a theory of pathogenesis based on this finding is consistent not only with our experimental findings, but with known in vitro effects of membrane soluble drugs on cell membranes and the clinical features following intra-arterial injections in both human subjects and in animals.
我们已经在麻醉动物模型中证明了动脉内注射地西泮的毒性以及盐酸氯胺酮的安全性。动脉内注射药物后坏疽的发病机制尚不清楚。临床报告和本实验表明，坏疽仅发生在注射高膜溶性药物之后。动脉内注射地西泮和硫喷妥钠后，可见毛细血管内皮细胞早期肿胀和破坏。我们认为，基于这一发现的发病机制理论不仅与我们的实验结果一致，而且与膜溶性药物对细胞膜的已知体外作用以及人类和动物动脉内注射后的临床特征一致。
