Pagano R R, Graham C W, Galligan M, Conner J T, Katz R L
Can Anaesth Soc J. 1978 Jan;25(1):50-2. doi: 10.1007/BF03006784.
A previously established rat model has been utilized to demonstrate that an acute inflammatory response occurs after high intravenous doses of lorazepam. This occurs only with high concentrations of drug equivalent to 20 times the normal clinical dosage in man. In contract, water soluble RO 21-3981 produces no vascular pathology in any dosage evaluated. It appears that propylene glycol may play a role in the pathogenesis of the intravascular injury observed.
先前建立的大鼠模型已被用于证明，静脉注射高剂量劳拉西泮后会发生急性炎症反应。这种情况仅在药物浓度高至相当于人类正常临床剂量20倍时才会出现。相比之下，水溶性RO 21-3981在任何评估剂量下均未产生血管病变。看来丙二醇可能在观察到的血管内损伤发病机制中起作用。
