Malik A S, Malik R H
Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Kuching.
Med J Malaysia. 2001 Dec;56(4):478-90.
A prospective study of 102 children with bacteriologically confirmed typhoid fever, admitted to Hospital Universiti Sains Malaysia over 5 years was conducted. The average age at presentation was 91.3 (range 6 - 159) months. Fever (900%), abdominal pain (56%) and diarrhoea (44%) were common symptoms. Findings included: hepatomegaly (85.3%), splenomegaly (27.5%), anaemia (31%), leukopenia (15%). thrombocytopenia (26%), positive Widal (62.5%) and Typhidot test (96%). Patients were treated with ampicillin (n = 54) or chloramphenicol (n = 49) and 1/3 developed complications like hepatitis (n = 19), bone marrow suppression (n = 8) and paralytic ileus (n = 7). A patient with splenomegaly, thrombocytopenia or leukopenia was at higher risk of developing complications.
对马来西亚理科大学医院5年间收治的102例细菌学确诊为伤寒热的儿童进行了一项前瞻性研究。就诊时的平均年龄为91.3个月（范围6 - 159个月）。发热（90%）、腹痛（56%）和腹泻（44%）是常见症状。检查结果包括：肝肿大（85.3%）、脾肿大（27.5%）、贫血（31%）、白细胞减少（15%）、血小板减少（26%）、肥达反应阳性（62.5%）和伤寒斑点试验阳性（96%）。患者接受氨苄青霉素（n = 54）或氯霉素（n = 49）治疗，三分之一的患者出现并发症，如肝炎（n = 19）、骨髓抑制（n = 8）和麻痹性肠梗阻（n = 7）。脾肿大、血小板减少或白细胞减少的患者发生并发症的风险更高。
