Seçmeer G, Kanra G, Cemeroğlu A P, Ozen H, Ceyhan M, Ecevit Z
Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Turk J Pediatr. 1995 Oct-Dec;37(4):339-41.
Enteric fever is still a common health problem in many countries, especially in children. Thus a ten-year retrospective study was carried out to evaluate the clinical and laboratory properties of enteric fever and the incidence of antimicrobial resistance in children. Throughout the past 10 years, Salmonella was isolated in 105 patients by blood culturing, 27 of which were Salmonella typhi. Most of the patients were above the age of two. Besides the typical symptoms and signs of enteric fever, 29.2% of the patients had some neurologic findings. Besides, 68.5% had elevated liver enzymes while only 44.4% had hepatomegaly with or without splenomegaly. Anemia was present in 44%, leukopenia in 16% and leukocytosis in 11.1% of the cases. The emergence of antimicrobial resistance during the last five years against ampicillin, chloramphenicol and trimetoprim-sulfamethoxazole has created a challenge in treating these infections.
伤寒在许多国家仍然是一个常见的健康问题，尤其是在儿童中。因此，开展了一项为期十年的回顾性研究，以评估儿童伤寒的临床和实验室特征以及抗菌药物耐药性的发生率。在过去10年中，通过血培养从105例患者中分离出沙门氏菌，其中27例为伤寒沙门氏菌。大多数患者年龄在两岁以上。除了伤寒的典型症状和体征外，29.2%的患者有一些神经系统表现。此外，68.5%的患者肝酶升高，而只有44.4%的患者有肝肿大，伴有或不伴有脾肿大。44%的病例存在贫血，16%的病例有白细胞减少，11.1%的病例有白细胞增多。过去五年中，针对氨苄西林、氯霉素和复方新诺明出现的抗菌药物耐药性给这些感染的治疗带来了挑战。
