Zidulka A, Desmeules M, Harvey J, Anthonisen N R
Can J Physiol Pharmacol. 1975 Oct;53(5):954-7. doi: 10.1139/y75-130.
The effect of acute obstruction of the right lower lobes (RLL) on the relative perfusion of different lung regions was studied using Xenon-133 in anesthetized artificially ventilated supine dogs. When the RLL were obstructed at functional residual capacity (FRC) and the rest of the lung was inflated to a transpulmonary pressure of 10 or 20 cm H2O (1 cm H2O = 94.1 N/m2), relative perfusion increased within 10 s to the obstructed lobes by 59 and 92%, respectively. The increase was less marked but still present (17 and 42%, respectively) when obstruction was maintained for 15 min, at a time when arterial hypoxemia had occurred. Hence, there was increased perfusion to an obstructed hypoxic region. The perfusion distribution correlated with the difference in alveolar pressure between the obstructed lobes and the unobstructed lobes such that relative perfusion was always increased to the low alveolar pressure region.
在麻醉状态下人工通气的仰卧位犬中，使用氙-133研究了右下叶（RLL）急性阻塞对不同肺区域相对灌注的影响。当RLL在功能残气量（FRC）时被阻塞，而肺的其余部分膨胀至跨肺压为10或20 cm H2O（1 cm H2O = 94.1 N/m2）时，阻塞肺叶的相对灌注在10秒内分别增加了59%和92%。当阻塞持续15分钟（此时已出现动脉低氧血症）时，增加幅度较小但仍然存在（分别为17%和42%）。因此，阻塞的低氧区域灌注增加。灌注分布与阻塞肺叶和未阻塞肺叶之间的肺泡压力差异相关，使得低肺泡压力区域的相对灌注总是增加。
