Belazi M, Fleva A, Drakoulakos D, Panayiotidou D
School of Dentistry, Department of Oral Medicine/Pathology, Aristotle University of Thessaloniki, Greece.
Int J STD AIDS. 2002 Jun;13(6):373-7. doi: 10.1258/095646202760029787.
This study sought to determine IgA, IgG antibodies to Candida albicans in whole saliva and serum from HIV-infected patients and to compare them to a group of healthy controls. The study population consisted of 34 HIV-infected individuals free of any other systemic diseases and thirty healthy controls. IgA concentrations in saliva and IgA and IgG concentrations in serum were measured by a micro enzyme-linked immunosorbent assay. No significant differences were observed in salivary and serum IgA antibodies to C. albicans between the two study groups. Serum IgG antibodies were found to be significantly lower in the HIV-infected (P < 0.05). No significant changes were observed in the specific activity of anti-Candida IgA and IgG antibodies in saliva and serum, in both the study groups. The undifferentiated levels of secretory-IgA antibodies to C. albicans in the patients' and the controls' saliva could be an indicator of the high immune response to opportunistic infections of the HIV-infected subjects, a fact that is verified by the lack of oral candidiasis in the patients' group. The low levels of IgG antibodies in the serum of the HIV-infected patients confirm the high immune response of them.
本研究旨在测定HIV感染患者全唾液和血清中抗白色念珠菌的IgA、IgG抗体，并将其与一组健康对照者进行比较。研究对象包括34例无其他全身性疾病的HIV感染者和30名健康对照者。采用微量酶联免疫吸附测定法检测唾液中的IgA浓度以及血清中的IgA和IgG浓度。两个研究组之间，唾液和血清中抗白色念珠菌的IgA抗体未观察到显著差异。发现HIV感染者血清中的IgG抗体显著较低（P < 0.05）。两个研究组的唾液和血清中抗念珠菌IgA和IgG抗体的比活性均未观察到显著变化。患者和对照者唾液中抗白色念珠菌分泌型IgA抗体的未分化水平可能表明HIV感染受试者对机会性感染具有高免疫反应，这一事实在患者组中无口腔念珠菌病得到了证实。HIV感染患者血清中IgG抗体水平较低证实了他们具有高免疫反应。
