Okwuasaba F K, Hamilton J T
Can J Physiol Pharmacol. 1975 Oct;53(5):972-7. doi: 10.1139/y75-135.
Metoclopramide (N-(diethylaminoethyl)-2-methoxy-4-amino-5-chlorobenzamide) (Mcp) at concentrations of 0.1 and 1.0 muM partially and significantly reduced the relaxations induced by adenosine 5'-triphosphate (ATP), adenosine diphosphate (ADP), and adenosine, was without effect on theophylline ethylenediamine whilst significantly potentiating noradrenaline on the atropine-pretreated (0.1 muM) taenia coli, rabbit ileum, and rat duodenum. Mcp (1.0 muM) decreased the inhibitory effects of ATP, ADP, and adenosine on peristalsis induced in the isolated guinea-pig ileum by a constant increase in intraluminal pressure, did not affect inhibition due to theophylline ethylenediamine, whilst it potentiated inhibition of peristalsis due to noradrenaline. It is proposed that this effect of Mcp may be a specific antagonistic action on receptors sensitive to the putative purinergic transmitter, ATP and ADP, and may be partly responsible for its observed facilitatatory action on peristalsis.
胃复安（N-（二乙氨基乙基）-2-甲氧基-4-氨基-5-氯苯甲酰胺）（Mcp）浓度为0.1和1.0μM时，能部分且显著降低由三磷酸腺苷（ATP）、二磷酸腺苷（ADP）和腺苷诱导的舒张作用，对氨茶碱乙二胺无影响，而在经阿托品预处理（0.1μM）的兔回肠、兔结肠带和大鼠十二指肠上能显著增强去甲肾上腺素的作用。Mcp（1.0μM）减弱了ATP、ADP和腺苷对通过腔内压力持续升高诱导的豚鼠离体回肠蠕动的抑制作用，对氨茶碱乙二胺引起的抑制无影响，同时增强了去甲肾上腺素对蠕动的抑制作用。有人提出，Mcp的这种作用可能是对假定的嘌呤能递质ATP和ADP敏感的受体的一种特异性拮抗作用，这可能部分解释了其对蠕动的促进作用。
