[一项关于阿尔茨海默病家族史的病例对照研究]
[A case-control study on family history of Alzheimer's disease].
作者信息
Yao Jiahong, Li Hui, Zhang Zhenxin
机构信息
Department of Epidemiology, Institute of Basic Medical Sciences, CAMS & PUMC, Beijing 100005, China.
出版信息
Zhonghua Liu Xing Bing Xue Za Zhi. 2002 Feb;23(1):54-6.
OBJECTIVE
To explore the relationship between Alzheimer's disease and its family history of the patients.
METHODS
Stratified analyses and logistic regression analysis were used to examine the association between Alzheimer's disease and its family history exposure in 127 cases and 254 matched controls from a population-based case-control study.
RESULTS
The risk of Alzheimer's disease was significantly higher in those who had at least one first-degree relative with dementia or major psychosis as compared to those who had no dementia or major relatives with psychosis (OR = 6.25; 8.33). Adjusted for age and level of education, family history of dementia was still associated with Alzheimer's disease positively (OR = 2.07).
CONCLUSION
This study provides evidence that familial aggregation of Alzheimer's disease might exist among people living Beijing.
目的
探讨阿尔茨海默病与其患者家族史之间的关系。
方法
采用分层分析和逻辑回归分析，对一项基于人群的病例对照研究中127例病例和254例匹配对照进行阿尔茨海默病与其家族史暴露之间的关联研究。
结果
与没有痴呆或精神病主要亲属的人相比，至少有一位患有痴呆或主要精神病的一级亲属的人患阿尔茨海默病的风险显著更高（比值比=6.25；8.33）。在调整年龄和教育水平后，痴呆家族史仍与阿尔茨海默病呈正相关（比值比=2.07）。
结论
本研究提供了证据表明，居住在北京的人群中可能存在阿尔茨海默病的家族聚集现象。
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