Shen Y
Institute of Mental Health, Beijing Medical University.
Zhonghua Shen Jing Jing Shen Ke Za Zhi. 1992 Oct;25(5):284-7, 317.
A case control study to assess the possible risk factors associated with Alzheimer's disease (AD) among Chinese population was conducted on 126 clinical diagnosed AD patients and 252 matched by sex, age, nationality non-demand neighborhood as control. Factors significantly associated with AD cases were: family history of dementia in first degree relatives, family history of psychoses in first degree relatives, few interests and heavy negative life events during individual's life time. Neither family history of Down's syndrome, antecedent history of head trauma, nor other condition that might support immune hypotheses were significantly associated with AD cases. The data from this study support the familial/genetic hypotheses of AD and also the role of psychosocial factors in AD.
一项病例对照研究在中国人群中展开，旨在评估与阿尔茨海默病（AD）相关的潜在风险因素。该研究选取了126名临床诊断为AD的患者，并以252名在性别、年龄、民族、居住社区等方面与之匹配的非AD患者作为对照。与AD病例显著相关的因素包括：一级亲属中有痴呆家族史、一级亲属中有精神病家族史、个人兴趣缺乏以及一生中经历过严重的负面生活事件。唐氏综合征家族史、头部外伤史以及其他可能支持免疫假说的情况均与AD病例无显著关联。本研究的数据支持AD的家族/遗传假说以及社会心理因素在AD发病中的作用。
