Gaitán-Cepeda Luis, Cashat-Cruz Miguel, Morales-Aguirre Jose Juan, Sánchez-Vargas Luis, Aquino-Garcia Sandra, Fragoso-Ríos Rodolfo, Cuairán-Ruidiaz Vicente, Avila-Figueroa Carlos
Oral Pathology Laboratory, Dental School, National Autonomous University of Mexico, Tlalpan, Mexico.
AIDS Patient Care STDS. 2002 Apr;16(4):151-6. doi: 10.1089/10872910252930858.
It has been proposed that HIV-related oral lesions (HIV-ROL) have a significant diagnostic and prognostic value for human immunodeficiency virus (HIV) infection in adult patients. However, in HIV-infected children, the relation between HIV-ROL and immune and virologic status is not well established. The principal objective of this paper is to assess the prevalence of HIV-related oral lesions (HIV-ROL) in Mexican HIV-infected children in relation to their immunologic status, viral load, and gender. Forty-eight HIV-infected children from Immunodeficiency Clinic, Child's Hospital of México, México City, were examined for oral pathology. The data obtained from medical records were: name, gender, age, route of infection, CD4 lymphocytes cells count/mL, HIV-1-RNA level of copies/mL (viral load), and type and time of treatment. The prevalence of HIV-ROL was 29.2%. Oral candidosis was the most prevalent oral lesion (20.8%) followed by periodontal and gingival disease (4.2%), herpes simplex (2.1%), and parotid enlargement (2.1%). There was no association between the prevalence of HIV-ROL and gender, immunological status, or viral load. The most frequent clinical form of oral candidosis was erythematous candidosis (12.5%, N = 6). Our results do not suggest a direct relationship between prevalence of HIV-ROL, severe immunodepression, and/or viral load > 100000 copies in this population.
有人提出，与人类免疫缺陷病毒（HIV）相关的口腔病变（HIV-ROL）对成年患者的HIV感染具有重要的诊断和预后价值。然而，在HIV感染儿童中，HIV-ROL与免疫和病毒学状态之间的关系尚未明确确立。本文的主要目的是评估墨西哥HIV感染儿童中与HIV相关的口腔病变（HIV-ROL）的患病率与其免疫状态、病毒载量和性别的关系。对来自墨西哥城墨西哥儿童医院免疫缺陷诊所的48名HIV感染儿童进行了口腔病理学检查。从病历中获得的数据包括：姓名、性别、年龄、感染途径、每毫升CD4淋巴细胞计数、每毫升HIV-1-RNA拷贝数水平（病毒载量）以及治疗类型和时间。HIV-ROL的患病率为29.2%。口腔念珠菌病是最常见的口腔病变（20.8%），其次是牙周和牙龈疾病（4.2%）、单纯疱疹（2.1%）和腮腺肿大（2.1%）。HIV-ROL的患病率与性别、免疫状态或病毒载量之间没有关联。口腔念珠菌病最常见的临床形式是红斑型念珠菌病（12.5%，N = 6）。我们的结果并不表明该人群中HIV-ROL的患病率、严重免疫抑制和/或病毒载量>100000拷贝之间存在直接关系。
