Amin Raouf S, Kimball Thomas R, Bean Judy A, Jeffries Jenny L, Willging J Paul, Cotton Robin T, Witt Sandra A, Glascock Betty J, Daniels Steven R
Department of Pulmonary Medicine, Allergy & Clinical Immunology, Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.
Am J Respir Crit Care Med. 2002 May 15;165(10):1395-9. doi: 10.1164/rccm.2105118.
Obstructive sleep apnea (OSA) has been shown to be an independent risk factor for cardiovascular disease in adults. However, there are severe limitations in the extent to which the cardiovascular consequences of OSA are being studied in children. To investigate the echocardiographic changes in children with OSA, right and left ventricular (RV, LV) dimensions and LV mass index and geometry were measured in 28 children with OSA and 19 children with primary snoring (PS). The study showed that LV mass index and relative wall thickness were greater in the OSA group compared with those with PS (p = 0.012 and p < 0.0001, respectively). An apnea-hypopnea index of more than 10 per hour was significantly associated with RV dimension above the 95th percentile (odds ratios, 6.7; 95% confidence interval, 1.4-32) and LV mass index above the 95th percentile (odds ratios, 11.2; confidence interval, 1.9-64). Abnormality of LV geometry was present in 15% of children with PS compared with 39% of children with OSA. We conclude that OSA in children is associated with increased LV mass.
阻塞性睡眠呼吸暂停（OSA）已被证明是成人心血管疾病的独立危险因素。然而，在儿童中对OSA心血管后果的研究程度存在严重局限性。为了研究OSA患儿的超声心动图变化，对28例OSA患儿和19例原发性打鼾（PS）患儿测量了右心室和左心室（RV、LV）尺寸、LV质量指数和几何形状。研究表明，与PS患儿相比，OSA组的LV质量指数和相对壁厚更大（分别为p = 0.012和p < 0.0001）。每小时呼吸暂停低通气指数超过10与第95百分位数以上的RV尺寸（优势比，6.7；95%置信区间，1.4 - 32）和第95百分位数以上的LV质量指数（优势比，11.2；置信区间，1.9 - 64）显著相关。PS患儿中有15%存在LV几何形状异常，而OSA患儿中这一比例为39%。我们得出结论，儿童OSA与LV质量增加有关。
