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RNA沉默:基因组的免疫系统。

RNA silencing: the genome's immune system.

作者信息

Plasterk Ronald H A

机构信息

Hubrecht Laboratory, Centre for Biomedical Genetics, Uppsalalaan 8, 3584 CT Utrecht, Netherlands.

出版信息

Science. 2002 May 17;296(5571):1263-5. doi: 10.1126/science.1072148.

Abstract

Genomes are databases sensitive to invasion by viruses. In recent years, a defense mechanism has been discovered, which turns out to be conserved among eukaryotes. The system can be compared to the immune system in several ways: It has specificity against foreign elements and the ability to amplify and raise a massive response against an invading nucleic acid. The latter property is beginning to be understood at the molecular level.

摘要

基因组是对病毒入侵敏感的数据库。近年来,人们发现了一种防御机制,事实证明这种机制在真核生物中是保守的。该系统在几个方面可与免疫系统相比较:它对外源元件具有特异性,并且具有扩增以及对入侵核酸产生大规模反应的能力。后一种特性正开始在分子水平上得到理解。

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