Xiao Z, Wang W, Han J, He X, Li J
Department of Gerontology, Xianya Hospital, Hunan Medical University, Changsha 410008.
Hunan Yi Ke Da Xue Xue Bao. 1999;24(3):251-2, 255.
To investigate the changes of tissue factor (TF) and tissue factor pathway inhibitor(TFPI) activities in patients with hypertension or coronary atherosclerotic heart (CAH) disease.
TF activity was measured by two-stage assay, and TFPI activity was detected according to Sandset's method.
Plasma TF activity in both patients with hypertension and patients with CAH disease was higher than that of normal control(P < 0.05).
Hypercoagulative state may be involved in the pathogenetic processes of hypertension and CAH diseases. TF and TFPI activities have the likelihood to become the accessory diagnostic indexes for hypertension and CAH diseases.
探讨高血压或冠状动脉粥样硬化性心脏病（CAH）患者组织因子（TF）和组织因子途径抑制物（TFPI）活性的变化。
采用两步法测定TF活性，按照桑德塞特方法检测TFPI活性。
高血压患者和CAH患者的血浆TF活性均高于正常对照组（P < 0.05）。
高凝状态可能参与高血压和CAH疾病的发病过程。TF和TFPI活性有可能成为高血压和CAH疾病的辅助诊断指标。
