Day C E, Phillips W A, Schurr P E
Artery. 1979 Feb;5(2):90-109.
A system of animal models potentially useful for the discovery and evaluation of new effective antiatherosclerotic agents is described. The models consist of a series of lipoprotein and atherosclerosis assays in rats, SEA Japanese quail and cynomolgus monkeys. SEA quail are particularly useful for detecting compounds that inhibit arterial cholesterol deposition. The use of this integrated system of models is illustrated with data on clofibrate, adamantyloxyaniline (a hypobetalipoproteinemic agent), and o,p'-DDD. Male SEA quail appear to be a quite satisfactory model for testing the effects of large numbers of compounds on atherosclerosis and are available in limited numbers to all qualified investigators in the field of atherosclerosis research for evaluation in their laboratories.
本文描述了一个可能有助于发现和评估新型有效抗动脉粥样硬化药物的动物模型系统。这些模型包括在大鼠、SEA日本鹌鹑和食蟹猴身上进行的一系列脂蛋白和动脉粥样硬化检测。SEA鹌鹑对于检测抑制动脉胆固醇沉积的化合物特别有用。通过氯贝丁酯、金刚烷氧基苯胺（一种降β脂蛋白血症药物）和邻，对'-滴滴滴的数据说明了该综合模型系统的应用。雄性SEA鹌鹑似乎是测试大量化合物对动脉粥样硬化影响的非常令人满意的模型，并且在动脉粥样硬化研究领域的所有合格研究人员可获得有限数量的该模型用于在其实验室进行评估。
