Vasilenko Iu K, Lisevitskaia L I, Frolova L M, Parfent'eva E P, Skul'te I V
Farmakol Toksikol. 1982 Sep-Oct;45(5):66-70.
Experiments on rabbits and white rats with experimental hyperlipidemia and atherosclerosis have shown that pentocyclic triterpenoids belonging to the alpha- and beta-amirin groups, of which saparal, glyciram and glycirenate are officinal drugs, are capable of reducing the level of cholesterol, beta-lipoproteins and triglycerides in the blood and that of cholesterol in aorta tissues. The effect of the compounds under study has been found to exceed the hypolipidemic action of the officinal antiatherosclerotic drugs, polysponine and cetamiphen, and to be noted for low toxicity. To screen hypolipidemic properties in the substances, an effective modification of experimental hyperlipidemia in rats has been offered.
对患有实验性高脂血症和动脉粥样硬化的兔子和白鼠进行的实验表明，属于α-和β-香树脂醇类的五环三萜类化合物（其中沙帕拉尔、甘西拉明和甘西雷纳酯为药用药物）能够降低血液中胆固醇、β-脂蛋白和甘油三酯的水平以及主动脉组织中胆固醇的水平。已发现所研究的这些化合物的作用超过了药用抗动脉粥样硬化药物多司泊宁和西他米芬的降血脂作用，且毒性较低。为了筛选物质的降血脂特性，已提出了一种对大鼠实验性高脂血症进行有效改良的方法。
