Hickey S, Gaylor J D, Kenny G N
Department of Anaesthesia, Glasgow Royal Infirmary, United Kingdom.
J Cardiothorac Vasc Anesth. 1996 Apr;10(3):352-5. doi: 10.1016/s1053-0770(96)80096-6.
This study was designed to investigate the effect of membrane oxygenator design and composition on the uptake and elimination of isoflurane.
Prospective, in vitro laboratory study.
Bioengineering laboratory.
Three types of membrane oxygenator were tested: the SM-35 (polydimethylsiloxane in sheet form), the CML (polypropylene in sheet form), and the SAFE II (polypropylene in hollow-fiber form). The oxygenators were incorporated into a standard cardiopulmonary bypass circuit.
Isoflurane was added to the oxygenator input gas and measured in exhaust gas and in (bovine) blood leaving the oxygenator at 1, 2, 3, 5, 7, 10, 15, and 20 minutes. The isoflurane vaporizer was then turned off, and samples were obtained at the same time intervals. The experiment was performed at 28 degrees C and 37 degrees C.
Uptake and elimination of isoflurane were slower via the SM-35 compared with the CML and the SAFE II (p < 0.01).
If isoflurane is administered during cardiopulmonary bypass, knowledge of the influence of oxygenator membrane composition on its pharmacokinetics is essential if patient awareness and unexpected cardiovascular depression are to be avoided.
本研究旨在调查膜式氧合器的设计和组成对异氟烷摄取和清除的影响。
前瞻性体外实验室研究。
生物工程实验室。
测试了三种类型的膜式氧合器：SM-35（片状聚二甲基硅氧烷）、CML（片状聚丙烯）和SAFE II（中空纤维状聚丙烯）。这些氧合器被纳入标准体外循环回路。
将异氟烷添加到氧合器输入气体中，并在1、2、3、5、7、10、15和20分钟时测量废气以及离开氧合器的（牛）血液中的异氟烷含量。然后关闭异氟烷蒸发器，并在相同时间间隔采集样本。实验在28摄氏度和37摄氏度下进行。
与CML和SAFE II相比，通过SM-35摄取和清除异氟烷的速度较慢（p < 0.01）。
如果在体外循环期间使用异氟烷，若要避免患者苏醒和意外的心血管抑制，了解氧合器膜组成对其药代动力学的影响至关重要。
