Gourlay Terence, Ballaux Philippe K, Draper Edward R C, Taylor Kenneth M
Department of Cardiothoracic Surgery, National Heart and Lung Institute, Imperial College Faculty of Medicine, London, UK.
Perfusion. 2002 May;17(3):191-8. doi: 10.1191/0267659102pf567oa.
The benefits of pulsatile flow during the period of cardiopulmonary bypass (CPB) applied during open-heart surgery remains controversial. We have developed a rodent (rat) model of CBP that has been designed to functionally mimic the clinical setting, principally, but not solely, for the study of pulsatile CPB. The successful development of this model centres on the design of the bypass circuitry and the surgical approach employed. The entire circuit is similar to clinical equipment in terms of its construction, configuration, performance, material surface area to blood volume ratio, and priming volume to blood volume ratio. The overall priming volume of the perfusion circuitry is less than 12 ml. Early studies confirm that the pumping technology functions well, gas exchange was adequate at all times, and blood pressure exhibited a normal CPB profile and haemodynanmic response to pulsatile blood flow. We conclude that this is an effective tool for investigating the pathophysiology of pulsatile blood flow during CPB.
在心脏直视手术中应用体外循环（CPB）期间搏动血流的益处仍存在争议。我们开发了一种CPB啮齿动物（大鼠）模型，该模型主要但并非唯一用于搏动性CPB研究，旨在从功能上模拟临床情况。该模型的成功开发主要围绕旁路循环系统的设计和所采用的手术方法。整个循环系统在结构、配置、性能、材料表面积与血容量比以及预充量与血容量比方面与临床设备相似。灌注循环系统的总体预充量小于12毫升。早期研究证实，该泵技术运行良好，气体交换始终充足，血压呈现正常的CPB曲线以及对搏动血流的血流动力学反应。我们得出结论，这是研究CPB期间搏动血流病理生理学的有效工具。
