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[小肠内感受器暴露于乳酸时血压及肠神经冲动活动的变化]

[Changes in blood pressure and impulse activity in intestinal nerves during exposure of small intestine interoreceptors to lactic acid].

作者信息

Lebedeva V A

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1975 Nov;61(11):1686-96.

PMID:1201795
Abstract

I. a. administration of threshold concentration (0.2 ml 7.8 mM) of lactic acid into the small intestine was found to increase afferent and efferent impulsation in the intestinal nerves as well as the systemic arterial blood pressure in anesthetized cats. Increase in the lactic acid concentration up to 250 mM/l resulted in two-phasic augmentation of the nerve responses and of the pressor reflexes. In the range from 7.8 to 62.5 mM/l of lactic acid concentration the absolute magnitude of pressor reflexes was 2.3 +/- 0.6--4.2 +/- 0.5 mm Hg. Further increase in the lactic acid concentration (up to 250 mM/l) produced on augmentation in the reflexes magnitude up to 18 +/- 2.8 mm Hg. A possible functional role of afferent impulses generated by the tissue receptors following an increase in metabolites concentration in the organs, is discussed.

摘要

I. a. 向麻醉猫的小肠内注入阈浓度(0.2毫升7.8毫摩尔)的乳酸,发现可增加肠神经的传入和传出冲动以及全身动脉血压。将乳酸浓度增至250毫摩尔/升会导致神经反应和升压反射呈双相增强。在乳酸浓度为7.8至62.5毫摩尔/升的范围内,升压反射的绝对幅度为2.3±0.6 - 4.2±0.5毫米汞柱。乳酸浓度进一步升高(至250毫摩尔/升)会使反射幅度增大至18±2.8毫米汞柱。文中讨论了器官内代谢物浓度升高后组织感受器产生的传入冲动可能具有的功能作用。

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