Lebedeva V A, Filippova L V, Chernigovskiĭ V N
Fiziol Zh SSSR Im I M Sechenova. 1976 Feb;62(2):264-74.
Perfusion of the small intestine of anesthetized cats with a solution having excessive CO2 and H+ concentration (pCO2 60 mm Hg; pH; 7.2; [HCO3-] 25 MM) produced a threshold reflex increase in the blood pressure. The subsequent increase of pCO2 to 380 mm Hg and decrease of pH to 6.4 evoked a gradual raise of the blood pressure (8.0+/-0.6 mm Hg) followed by the sharp increase of pressor reflexes amplitude within the range of pH 6.4--6.1. Tissue receptors were found to be essentially sensitive to solutions imitating metabolic acidosis (decrease of [HCO3-] within the physiological range of pH changes (pH 7.1--6.8). Solutions with pH 6.4--6.1 imitating respiratory acidosis (increase of pCO2) were more effective than those imitating metabolic acidosis. The possible role of interstitial pH changes in responses of the tissue chemoreceptors to CO2, is discussed.
用具有过高二氧化碳和氢离子浓度（pCO₂ 60毫米汞柱；pH值7.2；[HCO₃⁻] 25毫摩尔）的溶液灌注麻醉猫的小肠，会使血压出现阈值反射性升高。随后将pCO₂升高至380毫米汞柱并将pH值降至6.4，会使血压逐渐升高（8.0±0.6毫米汞柱），随后在pH值6.4 - 6.1范围内升压反射幅度急剧增加。发现组织感受器对模拟代谢性酸中毒的溶液（在pH值变化的生理范围内（pH值7.1 - 6.8）[HCO₃⁻]降低）基本敏感。模拟呼吸性酸中毒（pCO₂升高）的pH值6.4 - 6.1的溶液比模拟代谢性酸中毒的溶液更有效。讨论了组织间液pH值变化在组织化学感受器对二氧化碳反应中的可能作用。
