Eckardt V F, Holtermüller K H
Digestion. 1975;13(1-2):1-7. doi: 10.1159/000197689.
The purpose of this study was to evaluate the effect of intravenous pentagastrin and gastric alkalinization on the lower esophageal sphincter (LES) pressure in seven patients with diffuse esophageal spasm as compared to nine normal controls. Intravenous injections of 0.2 and 0.4 mug pentagastrin/kg body weight increased LES pressure significantly more in patients than in control subjects (p less than 0.05, p less than 0.01). Following gastric alkalinization both groups showed increases in LES pressure, but these were significantly greater for patients with diffuse esophageal spasm (p less than 0.05) than for controls. The results of our study indicate that the LES in patients with diffuse esophageal spasm is supersensitive to pentagastrin and gastric alkalinization.
本研究的目的是评估静脉注射五肽胃泌素和胃碱化对7例弥漫性食管痉挛患者下食管括约肌（LES）压力的影响，并与9例正常对照者进行比较。静脉注射0.2和0.4μg五肽胃泌素/千克体重后，患者LES压力的升高显著高于对照者（p<0.05，p<0.01）。胃碱化后，两组LES压力均升高，但弥漫性食管痉挛患者的升高幅度显著大于对照组（p<0.05）。我们的研究结果表明，弥漫性食管痉挛患者的LES对五肽胃泌素和胃碱化超敏感。
