Jennewein H M, Waldeck F, Siewert R, Weiser F, Thimm R
Gut. 1973 Nov;14(11):861-4. doi: 10.1136/gut.14.11.861.
The effect of glucagon on the pressure inside the lower oesophageal sphincter in conscious human subjects and anaesthetized dogs was investigated using the continuous withdrawal method. Glucagon causes a decrease in sphincteric resting pressure in both man and dog and antagonizes the pentagastrin-induced pressure increase of the lower oesophageal sphincter. In experiments on isolated muscle strips of the lower oesophageal sphincter of dogs glucagon decreases the tension and antagonizes the increase in tension induced by pentagastrin. The elevated pressure in patients suffering from achalasia is significantly reduced by glucagon.
采用连续回撤法研究了胰高血糖素对清醒人体受试者和麻醉犬下食管括约肌内压力的影响。胰高血糖素可使人和犬的括约肌静息压力降低，并拮抗五肽胃泌素引起的下食管括约肌压力升高。在犬下食管括约肌离体肌条实验中，胰高血糖素可降低张力，并拮抗五肽胃泌素引起的张力升高。胰高血糖素可使贲门失弛缓症患者升高的压力显著降低。
