Kennedy I J, Sampath K
V V Classic Matriculation School, Tuticorin, India.
J Environ Biol. 2001 Oct;22(4):267-71.
Toxicity of methyl parathion was studied on survival of Rana tigrina tadpoles. The LC50 values for short-term (upto 96 h) and long term studies (hatching to froglet) were determined. The LC50 values for 96 h and the total larval period were 4.36 and 1.30 ppm respectively. The toxicity of methyl parathion enchanced in relation to increase in concentration and duration. Teratological defects such as scoliosis and failure in emergence of fore limb were noticed. Safe levels were calculated for short-term (0.1 ppm) and long-term (0.03 ppm) studies. The present work stresses the neccessity of long term study especially for the developing amphibians.
研究了甲基对硫磷对虎纹蛙蝌蚪存活的毒性。测定了短期（长达96小时）和长期研究（从孵化到幼蛙）的半数致死浓度（LC50）值。96小时和整个幼体期的LC50值分别为4.36 ppm和1.30 ppm。甲基对硫磷的毒性随着浓度和暴露时间的增加而增强。观察到了脊柱侧凸和前肢无法伸出等致畸缺陷。计算了短期研究（0.1 ppm）和长期研究（0.03 ppm）的安全水平。本研究强调了长期研究的必要性，特别是对于发育中的两栖动物。
