Ito Masanori, Haruma Ken, Kaya Shunji, Kai Hirohisa, Masuda Hiroshi, Ohta Masahiro, Sumii Masaharu, Tanaka Shinji, Yoshihara Masaharu, Chayama Kazuaki
First Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
Dig Dis Sci. 2002 May;47(5):1080-5. doi: 10.1023/a:1015042208224.
We investigated serum levels of anti-parietal cell antibody (APCA) in relation to various gastric diseases. Subjects were 224 Japanese patients including 58 with gastric cancer. All patients underwent gastroscopy, and APCA was investigated by enzyme-linked immunosorbent assay. Unexpectedly, there was no difference in APCA levels between patients with gastric cancer and those with gastritis. Among H. pylori-positive patients, APCA levels were closely correlated with grades of atrophy when no gastric cancer was present, but no correlation was found when gastric cancer was present. APCA-negative gastric cancer was found mainly in males and was characterized by massive infiltration of neutrophils in the background mucosa. The 24 patients with gastric cancer were APCA-negative and showed low pepsinogen levels. The odds ratio for the incidence of gastric cancer in these patients was 7.90 (95% CI 3.4-18.4). This suggests APCA-negative gastric cancer is the predominant form of gastric cancer in Japan.
我们研究了抗壁细胞抗体（APCA）血清水平与各种胃部疾病的关系。研究对象为224名日本患者，其中58例患有胃癌。所有患者均接受了胃镜检查，并通过酶联免疫吸附测定法检测APCA。出乎意料的是，胃癌患者和胃炎患者的APCA水平没有差异。在幽门螺杆菌阳性患者中，当不存在胃癌时，APCA水平与萎缩程度密切相关，但存在胃癌时未发现相关性。APCA阴性胃癌主要见于男性，其特征是背景黏膜中有大量中性粒细胞浸润。24例胃癌患者APCA阴性且胃蛋白酶原水平较低。这些患者患胃癌的比值比为7.90（95%可信区间3.4 - 18.4）。这表明APCA阴性胃癌是日本胃癌的主要形式。
