喷他脒、乙胺嘧啶、甲氧苄啶和磺胺类药物对曲霉属菌种的体外活性。
In vitro activities of pentamidine, pyrimethamine, trimethoprim, and sulfonamides against Aspergillus species.
作者信息
Afeltra Javier, Meis Jacques F G M, Vitale Roxana G, Mouton Johan W, Verweij Paul E
机构信息
Department of Medical Microbiology, University Medical Center Nijmegen, The Netherlands.
出版信息
Antimicrob Agents Chemother. 2002 Jun;46(6):2029-31. doi: 10.1128/AAC.46.6.2029-2031.2002.
Abstract
The susceptibilities of 70 strains of Aspergillus species were tested against seven different sulfa drugs and pentamidine by a microdilution method with RPMI 1640 and yeast nitrogen base media. Sulfamethoxazole, sulfadiazine, and pentamidine were active in vitro. The MICs obtained with RPMI 1640 were significantly higher than those with yeast nitrogen base. More studies are needed to further elucidate the action of these drugs.
摘要
采用含RPMI 1640和酵母氮源培养基的微量稀释法，对70株曲霉菌株针对7种不同磺胺类药物和喷他脒的敏感性进行了检测。磺胺甲恶唑、磺胺嘧啶和喷他脒在体外具有活性。用RPMI 1640获得的最低抑菌浓度显著高于用酵母氮源培养基获得的最低抑菌浓度。需要更多研究来进一步阐明这些药物的作用。
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