Bartlett M S, Shaw M M, Smith J W, Meshnick S R
Department of Pathology and Laboratory Medicine, Indiana University Medical Center, Indianapolis, USA.
Antimicrob Agents Chemother. 1998 Apr;42(4):934-5. doi: 10.1128/AAC.42.4.934.
Sulfamethoxazole is the component of co-trimoxazole responsible for its efficacy against Pneumocystis carinii pneumonia, but this drug is associated with frequent adverse effects. Sulfamethoxypyridazine is significantly more effective than sulfamethoxazole against a murine model of P. carinii and might be a candidate for testing in infected patients.
磺胺甲恶唑是复方新诺明中对卡氏肺孢子虫肺炎有效的成分,但该药物常伴有不良反应。磺胺甲氧哒嗪在针对卡氏肺孢子虫的小鼠模型上比磺胺甲恶唑显著更有效,可能是用于感染患者测试的候选药物。