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β-内酰胺类药物对产碳青霉烯水解金属β-内酰胺酶的铜绿假单胞菌所致实验性肺炎的治疗效果。

Efficacy of beta-lactams for treating experimentally induced pneumonia due to a carbapenem-hydrolyzing metallo-beta-lactamase-producing strain of Pseudomonas aeruginosa.

作者信息

Bellais Samuel, Mimoz Olivier, Léotard Sophie, Jacolot Anne, Petitjean Olivier, Nordmann Patrice

机构信息

Service de Bactériologie-Virologie-Hygiène, Hôpital de Bicêtre, Assistance Publique-Hôpitaux de Paris, Faculté de Médecine de Paris-Sud, 94275 Le Kremlin-Bicêtre, France.

出版信息

Antimicrob Agents Chemother. 2002 Jun;46(6):2032-4. doi: 10.1128/AAC.46.6.2032-2034.2002.

DOI:10.1128/AAC.46.6.2032-2034.2002
PMID:12019134
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC127240/
Abstract

A rat pneumonia model was established with a Pseudomonas aeruginosa strain that produced the plasmid-encoded metallocarbapenemase VIM-2. A significant decrease in lung bacterial titers was observed when imipenem, cefepime, ceftazidime, and piperacillin-tazobactam were given at the highest doses recommended for humans, despite their high MICs. Aztreonam at high doses produced a similar decrease in bacterial titers.

摘要

用一株产生质粒编码的金属碳青霉烯酶VIM-2的铜绿假单胞菌建立了大鼠肺炎模型。当给予亚胺培南、头孢吡肟、头孢他啶和哌拉西林-他唑巴坦人类推荐的最高剂量时，尽管它们的最低抑菌浓度（MIC）很高，但肺部细菌滴度仍显著降低。高剂量的氨曲南也使细菌滴度出现类似的降低。

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本文引用的文献

1
Metallo-beta-lactamases in clinical Pseudomonas isolates in Taiwan and identification of VIM-3, a novel variant of the VIM-2 enzyme.台湾临床分离的假单胞菌中的金属β-内酰胺酶以及VIM-2酶新变体VIM-3的鉴定
Antimicrob Agents Chemother. 2001 Aug;45(8):2224-8. doi: 10.1128/AAC.45.8.2224-2228.2001.
2
Plasmid-encoded metallo-beta-lactamase (IMP-6) conferring resistance to carbapenems, especially meropenem.质粒编码的金属β-内酰胺酶（IMP-6）赋予对碳青霉烯类抗生素，尤其是美罗培南的耐药性。
Antimicrob Agents Chemother. 2001 May;45(5):1343-8. doi: 10.1128/AAC.45.5.1343-1348.2001.
3
IMP-4, a novel metallo-beta-lactamase from nosocomial Acinetobacter spp. collected in Hong Kong between 1994 and 1998.IMP-4，一种于1994年至1998年期间在香港收集的医院不动杆菌属中的新型金属β-内酰胺酶。
Antimicrob Agents Chemother. 2001 Mar;45(3):710-4. doi: 10.1128/AAC.45.3.710-714.2001.
4
Molecular heterogeneity of bla(VIM-2)-containing integrons from Pseudomonas aeruginosa plasmids encoding the VIM-2 metallo-beta-lactamase.来自编码VIM-2金属β-内酰胺酶的铜绿假单胞菌质粒的含bla(VIM-2)整合子的分子异质性
FEMS Microbiol Lett. 2001 Feb 20;195(2):145-50. doi: 10.1111/j.1574-6968.2001.tb10512.x.
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Characterization of Class 1 integrons from Pseudomonas aeruginosa that contain the bla(VIM-2) carbapenem-hydrolyzing beta-lactamase gene and of two novel aminoglycoside resistance gene cassettes.对含有bla(VIM-2)碳青霉烯水解β-内酰胺酶基因的铜绿假单胞菌1类整合子以及两个新型氨基糖苷类耐药基因盒的鉴定。
Antimicrob Agents Chemother. 2001 Feb;45(2):546-52. doi: 10.1128/AAC.45.2.546-552.2001.
6
Occurrence of a new metallo-beta-lactamase IMP-4 carried on a conjugative plasmid in Citrobacter youngae from the People's Republic of China.在中国一株杨氏柠檬酸杆菌中，一种携带在接合性质粒上的新型金属β-内酰胺酶IMP-4的出现。
FEMS Microbiol Lett. 2001 Jan 1;194(1):53-7. doi: 10.1111/j.1574-6968.2001.tb09445.x.
7
Carbapenem-hydrolysing VIM-2 metallo- beta-lactamase in Pseudomonas aeruginosa from Greece.希腊铜绿假单胞菌中可水解碳青霉烯类的VIM-2金属β-内酰胺酶
J Antimicrob Chemother. 2000 Dec;46(6):1041-2. doi: 10.1093/jac/46.6.1041.
8
Hospital outbreak of carbapenem-resistant Pseudomonas aeruginosa producing VIM-1, a novel transferable metallo-beta-lactamase.医院内产新型可转移金属β-内酰胺酶VIM-1的耐碳青霉烯铜绿假单胞菌暴发。
Clin Infect Dis. 2000 Nov;31(5):1119-25. doi: 10.1086/317448. Epub 2000 Nov 6.
9
Carbapenemases: a problem in waiting?碳青霉烯酶：一个亟待解决的问题？
Curr Opin Microbiol. 2000 Oct;3(5):489-95. doi: 10.1016/s1369-5274(00)00128-4.
10
Characterization of VIM-2, a carbapenem-hydrolyzing metallo-beta-lactamase and its plasmid- and integron-borne gene from a Pseudomonas aeruginosa clinical isolate in France.VIM-2的特性研究，VIM-2是一种可水解碳青霉烯类的金属β-内酰胺酶及其来自法国一株铜绿假单胞菌临床分离株的质粒和整合子携带基因。
Antimicrob Agents Chemother. 2000 Apr;44(4):891-7. doi: 10.1128/AAC.44.4.891-897.2000.