慢病毒裂解肽1会扰乱粘质沙雷氏菌的外膜和内膜。
Lentivirus lytic peptide 1 perturbs both outer and inner membranes of Serratia marcescens.
作者信息
Phadke Shruti M, Lazarevic Vanja, Bahr Caroline C, Islam Kazi, Stolz Donna Beer, Watkins Simon, Tencza Sarah B, Vogel Hans J, Montelaro Ronald C, Mietzner Timothy A
机构信息
Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA.
出版信息
Antimicrob Agents Chemother. 2002 Jun;46(6):2041-5. doi: 10.1128/AAC.46.6.2041-2045.2002.
Abstract
Bis-lentivirus lytic protein 1 (Bis-LLP1) and polymyxin B exhibited similar killing activities against Serratia marcescens. By electron microscopy, bis-LLP1 interacted with the outer and cytoplasmic bacterial membranes, while polymyxin B affected only the outer membrane. The results of standard biochemical probes supported the findings of the electron microscopy studies, suggesting that these antimicrobial peptides have different mechanisms of action.
摘要
双慢病毒裂解蛋白1（Bis-LLP1）和多粘菌素B对粘质沙雷氏菌表现出相似的杀伤活性。通过电子显微镜观察，Bis-LLP1与细菌的外膜和细胞质膜相互作用，而多粘菌素B仅影响外膜。标准生化探针的结果支持了电子显微镜研究的结果，表明这些抗菌肽具有不同的作用机制。
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