肽 YY：一种潘氏细胞抗菌肽，可维持肠道共生。
Peptide YY: A Paneth cell antimicrobial peptide that maintains gut commensalism.
机构信息
Department of Medicine, University of Chicago, Chicago, IL, USA.
Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, USA.
出版信息
Science. 2023 Aug 4;381(6657):502-508. doi: 10.1126/science.abq3178. Epub 2023 Aug 3.
Abstract
The mammalian gut secretes a family of multifunctional peptides that affect appetite, intestinal secretions, and motility whereas others regulate the microbiota. We have found that peptide YY (PYY), but not endocrine PYY, acts as an antimicrobial peptide (AMP) expressed by gut epithelial paneth cells (PC). PC-PYY is packaged into secretory granules and is secreted into and retained by surface mucus, which optimizes PC-PYY activity. Although PC-PYY shows some antibacterial activity, it displays selective antifungal activity against virulent hyphae-but not the yeast form. PC-PYY is a cationic molecule that interacts with the anionic surfaces of fungal hyphae to cause membrane disruption and transcriptional reprogramming that selects for the yeast phenotype. Hence, PC-PYY is an antifungal AMP that contributes to the maintenance of gut fungal commensalism.
摘要
哺乳动物肠道分泌出一族多功能肽，这些肽影响食欲、肠道分泌和运动，而其他肽则调节微生物群。我们发现，肽 YY（PYY）而不是内分泌 PYY，作为一种由肠道上皮细胞潘氏细胞（PC）表达的抗菌肽（AMP）。PC-PYY 被包装到分泌颗粒中，并分泌到表面黏液中并被其保留，这优化了 PC-PYY 的活性。尽管 PC-PYY 显示出一些抗菌活性，但它对毒力菌丝表现出选择性抗真菌活性 - 而不是酵母形式。PC-PYY 是一种阳离子分子，与真菌菌丝的阴离子表面相互作用，导致膜破裂和转录重编程，从而选择酵母表型。因此，PC-PYY 是一种抗真菌 AMP，有助于维持肠道真菌共生关系。
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