Kolar M, Vagnerova I, Latal T, Urbanek K, Typovska H, Hubacek J, Papajik T, Raida L, Faber E
Department of Microbiology, Faculty of Medicine, Palackỳ University Olomouc, Czech Republic.
New Microbiol. 2002 Apr;25(2):205-12.
Very important bacterial pathogens found in hematological patients at present are vancomycin-resistant enterococci (VRE). The main goal of this retrospective study was to assess their occurrence in relation to antibiotic use. We isolated 1918 Enterococcus strains, in toto, 138 (7.2%) of which proved to be VRE. The VRE most frequently identified were Enterococcus faecium VanA (77%) and Enterococcusfaecalis VanB (12%), mostly isolated from stools (57%). Comparing the development of the selection pressure of antibiotics and percentage of VRE in each period of observation, an effect of the administration of each antibiotic group on the occurrence of VRE can be presumed. A reduction in the administration of third generation cephalosporins, glycopeptides and fluoroquinolones and its replacement by penicillin antibiotics combined with inhibitors of bacterial beta-lactamases, contributed to the cessation of VRE incidence and succeeding reduced occurrence from 15.1% in the second half of 1998 to 6.1% in the first half of 2000.
目前在血液学患者中发现的非常重要的细菌病原体是耐万古霉素肠球菌（VRE）。这项回顾性研究的主要目的是评估它们的发生与抗生素使用的关系。我们总共分离出1918株肠球菌菌株，其中138株（7.2%）被证明是VRE。最常鉴定出的VRE是粪肠球菌VanA（77%）和屎肠球菌VanB（12%），大多从粪便中分离出来（57%）。比较每个观察期抗生素选择压力的发展和VRE的百分比，可以推测每个抗生素组的使用对VRE发生的影响。第三代头孢菌素、糖肽类和氟喹诺酮类药物的使用减少，并被青霉素类抗生素与细菌β-内酰胺酶抑制剂联合使用所取代，这有助于VRE发病率的停止，并使随后的发生率从1998年下半年的15.1%降至2000年上半年的6.1%。
