Toungoussova S, Caugant D A, Sandven P, Mariandyshev A O, Bjune G
Department of International Health, the Faculty of Medicine, University of Oslo, Blindern, Norway.
Int J Tuberc Lung Dis. 2002 May;6(5):406-14.
The Archangels oblast, Russia, 1998-2000.
To study Mycobacterium tuberculosis resistance to anti-tuberculosis drugs in the Archangels oblast, and to reveal risk factors for the development of drug-resistant tuberculosis.
The drug susceptibility of strains isolated from 119 patients with pulmonary tuberculosis was studied using the BACTEC method. Medical records of the patients were reviewed, retrospectively, to identify factors associated with drug resistance.
Sixty-seven strains (56.3%) were resistant to at least one anti-tuberculosis drug. The highest rates of resistance were observed for streptomycin and isoniazid: respectively 40.4% and 66.7% of strains isolated from newly and previously treated patients were resistant to streptomycin, and respectively 37.1% and 73.3% of strains isolated from newly and previously treated patients were resistant to isoniazid. Thirty of the 119 strains (25.2%) were multidrug-resistant. Multidrug resistance was four times higher among previously treated patients than among new patients. A history of previous or interrupted treatment for tuberculosis and being female were significantly associated with drug resistance.
Drug-resistant tuberculosis is an important problem in the Archangels oblast, Russia. The spread of drug resistance is attributed to several risk factors. Being female and evidence of previous treatment for tuberculosis are risk factors for the development of drug-resistant tuberculosis in the Archangels oblast. Patients with drug-resistant tuberculosis also showed a higher risk of interrupting their treatment.
俄罗斯阿尔汉格尔斯克州，1998 - 2000年。
研究俄罗斯阿尔汉格尔斯克州结核分枝杆菌对抗结核药物的耐药情况，并揭示耐多药结核病发生的危险因素。
采用BACTEC法研究从119例肺结核患者分离出的菌株的药物敏感性。回顾性查阅患者的病历，以确定与耐药相关的因素。
67株（56.3%）对至少一种抗结核药物耐药。链霉素和异烟肼的耐药率最高：从新治疗患者和既往治疗患者中分离出的菌株分别有40.4%和66.7%对链霉素耐药，从新治疗患者和既往治疗患者中分离出的菌株分别有37.1%和73.3%对异烟肼耐药。119株中有30株（25.2%）为耐多药。既往治疗患者的耐多药率是新患者的4倍。既往有过结核病治疗史或治疗中断以及女性与耐药显著相关。
耐多药结核病是俄罗斯阿尔汉格尔斯克州的一个重要问题。耐药的传播归因于几个危险因素。女性以及既往有结核病治疗史是俄罗斯阿尔汉格尔斯克州耐多药结核病发生的危险因素。耐多药结核病患者中断治疗的风险也更高。
