Zinkernagel Rolf M
Institute for Experimental Immunology, University Hospital, CH-8091 Zurich, Switzerland.
Ann N Y Acad Sci. 2002 Apr;958:3-6. doi: 10.1111/j.1749-6632.2002.tb02942.x.
This review summarizes findings that indicate that immune reactions of T and B cells depend on thresholds of the binding avidity of the receptor, on antigen amounts, on the time period during which antigen is available in secondary lymphatic tissues, as well as on the detection methods used. Usually immunologically ignored, strictly extralymphatic host cells or their antigens may be released by infection or immunopathology to reach lymphatic organs and induce autoimmune diseases. If we know the infection, we call the disease immunopathologically mediated; if we do not recognize or know it, we call the disease autoimmune.
本综述总结了一些研究结果，这些结果表明T细胞和B细胞的免疫反应取决于受体结合亲和力的阈值、抗原量、抗原在次级淋巴组织中存在的时间段以及所使用的检测方法。通常被免疫忽视的、严格位于淋巴外的宿主细胞或其抗原，可能因感染或免疫病理作用而释放，从而到达淋巴器官并引发自身免疫性疾病。如果我们知道感染情况，就将这种疾病称为免疫病理介导的；如果我们未识别或了解感染情况，就将这种疾病称为自身免疫性疾病。
