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Vaccination with tumor cells pulsed with foreign peptide induces immunity to the tumor itself.用外源肽脉冲处理的肿瘤细胞进行疫苗接种可诱导对肿瘤本身的免疫。
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2
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Vaccination with an adenoviral vector encoding the tumor antigen directly linked to invariant chain induces potent CD4(+) T-cell-independent CD8(+) T-cell-mediated tumor control.用编码与恒定链直接相连的肿瘤抗原的腺病毒载体进行疫苗接种可诱导有效的不依赖CD4(+) T细胞的CD8(+) T细胞介导的肿瘤控制。
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Cancers (Basel). 2021 Jan 9;13(2):223. doi: 10.3390/cancers13020223.

本文引用的文献

1
Immunologic and clinical responses after vaccinations with peptide-pulsed dendritic cells in metastatic renal cancer patients.转移性肾癌患者接种肽脉冲树突状细胞后的免疫和临床反应。
Cancer Res. 2006 Jun 1;66(11):5910-8. doi: 10.1158/0008-5472.CAN-05-3905.
2
Vaccination with a HER2/neu peptide induces intra- and inter-antigenic epitope spreading in patients with early stage breast cancer.用HER2/neu肽进行疫苗接种可诱导早期乳腺癌患者体内和抗原间表位扩展。
Surgery. 2006 Mar;139(3):407-18. doi: 10.1016/j.surg.2005.06.059.
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Cross-presentation: underlying mechanisms and role in immune surveillance.交叉呈递：潜在机制及其在免疫监视中的作用
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New spectrum of allorecognition pathways: implications for graft rejection and transplantation tolerance.同种异体识别途径的新谱：对移植排斥和移植耐受的影响。
Curr Opin Immunol. 2004 Oct;16(5):550-7. doi: 10.1016/j.coi.2004.07.011.
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The promise of cancer vaccines.癌症疫苗的前景。
Nat Rev Cancer. 2004 May;4(5):401-11. doi: 10.1038/nrc1359.
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Determinant spreading associated with clinical response in dendritic cell-based immunotherapy for malignant melanoma.基于树突状细胞的恶性黑色素瘤免疫治疗中与临床反应相关的决定因素扩散
Clin Cancer Res. 2003 Mar;9(3):998-1008.
7
Determinant spreading and tumor responses after peptide-based cancer immunotherapy.基于肽的癌症免疫治疗后的决定簇扩散和肿瘤反应。
Trends Immunol. 2003 Feb;24(2):58-61. doi: 10.1016/s1471-4906(02)00029-7.
8
Making and breaking tolerance.建立与打破耐受性。
Curr Opin Immunol. 2002 Dec;14(6):744-59. doi: 10.1016/s0952-7915(02)00406-5.
9
Antiinfection immunity and autoimmunity.抗感染免疫与自身免疫。
Ann N Y Acad Sci. 2002 Apr;958:3-6. doi: 10.1111/j.1749-6632.2002.tb02942.x.
10
Checkpoints in the regulation of T helper 1 responses.辅助性T细胞1应答调控中的检查点。
Curr Top Microbiol Immunol. 2002;266:23-39. doi: 10.1007/978-3-662-04700-2_3.

用外源肽脉冲处理的肿瘤细胞进行疫苗接种可诱导对肿瘤本身的免疫。

Vaccination with tumor cells pulsed with foreign peptide induces immunity to the tumor itself.

作者信息

Schlingmann Tobias R, Rininsland Frauke H, Bartholomae Wolf C, Kuekrek Haydar, Lehmann Paul V, Tary-Lehmann Magdalena

机构信息

Department of Pathology, Case Western Reserve University, Cleveland, OH, USA.

出版信息

Clin Immunol. 2009 Oct;133(1):45-51. doi: 10.1016/j.clim.2009.06.004. Epub 2009 Jul 9.

DOI:10.1016/j.clim.2009.06.004
PMID:19589730
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2744850/
Abstract

EMT-6 mammary carcinoma and B16 melanoma (B16M) cells are lethal and barely immunogenic in syngeneic BALB/c and C57BL/6 mice, respectively. We show that mice vaccinated with tumor cells pulsed with a MHC class I-restricted peptide develop a T cell response, not only to the peptide, but also to the unpulsed tumor. These mice display protective immunity against the unpulsed tumor, and their T cells adoptively transfer tumor-specific protection to immunodeficient SCID mice. Our data have implications for cancer vaccine strategies. Grafting a single well-defined foreign peptide on tumor cells might suffice to trigger anti-tumor immunity.

摘要

EMT-6乳腺癌细胞和B16黑色素瘤（B16M）细胞分别在同基因的BALB/c和C57BL/6小鼠中具有致死性且几乎没有免疫原性。我们发现，用与主要组织相容性复合体I类（MHC I类）限制性肽脉冲处理过的肿瘤细胞进行疫苗接种的小鼠，不仅会产生针对该肽的T细胞反应，还会产生针对未脉冲处理的肿瘤的T细胞反应。这些小鼠对未脉冲处理的肿瘤表现出保护性免疫，并且它们的T细胞能将肿瘤特异性保护作用过继转移给免疫缺陷的严重联合免疫缺陷（SCID）小鼠。我们的数据对癌症疫苗策略具有启示意义。在肿瘤细胞上嫁接单一明确的外源肽可能足以触发抗肿瘤免疫。