JAK-STAT signaling in asthma.
作者信息
Pernis Alessandra B, Rothman Paul B
机构信息
Department of Medicine, Columbia University, New York, New York 10032, USA.
出版信息
J Clin Invest. 2002 May;109(10):1279-83. doi: 10.1172/JCI15786.
Abstract
摘要
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本文引用的文献
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Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet.在缺乏T-bet的小鼠中出现与人类哮喘一致的自发性气道变化。
Science. 2002 Jan 11;295(5553):336-8. doi: 10.1126/science.1065544.
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T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells.在淋巴细胞和髓细胞中，T-bet可被γ干扰素迅速诱导产生。
Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15137-42. doi: 10.1073/pnas.261570598.
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Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types.白细胞介素-13在三种人类气道细胞类型中诱导出截然不同的转录程序。
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Signal transducer and activator of transcription 6 (STAT-6) expression and function in asthmatic bronchial epithelium.信号转导及转录激活因子6（STAT-6）在哮喘支气管上皮中的表达与功能
J Allergy Clin Immunol. 2001 Nov;108(5):832-8. doi: 10.1067/mai.2001.119554.
5
Role of T-bet in commitment of TH1 cells before IL-12-dependent selection.T-bet在白细胞介素-12依赖性选择之前对辅助性T细胞1（TH1细胞）分化的作用
Science. 2001 Jun 8;292(5523):1907-10. doi: 10.1126/science.1059835.
6
Stat6 is necessary and sufficient for IL-4's role in Th2 differentiation and cell expansion.Stat6对于白细胞介素-4在辅助性T细胞2（Th2）分化和细胞扩增中的作用是必需且充分的。
J Immunol. 2001 Jun 15;166(12):7276-81. doi: 10.4049/jimmunol.166.12.7276.
7
Signal transducer and activator of transcription 6 controls chemokine production and T helper cell type 2 cell trafficking in allergic pulmonary inflammation.信号转导及转录激活因子6调控变应性肺炎症中趋化因子的产生及2型辅助性T细胞的迁移。
J Exp Med. 2001 May 7;193(9):1087-96. doi: 10.1084/jem.193.9.1087.
8
TH2 cytokine-associated transcription factors in atopic and nonatopic asthma: evidence for differential signal transducer and activator of transcription 6 expression.特应性和非特应性哮喘中与TH2细胞因子相关的转录因子：转录信号调节因子6表达差异的证据
J Allergy Clin Immunol. 2001 Apr;107(4):586-91. doi: 10.1067/mai.2001.114883.
9
Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets.细胞因子基因的早期转录和沉默是T辅助细胞亚群极化的基础。
Immunity. 2001 Mar;14(3):205-15. doi: 10.1016/s1074-7613(01)00103-0.
10
Temporal association between airway hyperresponsiveness and airway eosinophilia in ovalbumin-sensitized mice.卵清蛋白致敏小鼠气道高反应性与气道嗜酸性粒细胞增多之间的时间关联。
Am J Respir Crit Care Med. 2001 Mar;163(3 Pt 1):721-30. doi: 10.1164/ajrccm.163.3.2005010.
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