Mega Michael S, Small Gary W, Xu Mina L, Felix Jenaro, Manese Mario, Tran Nha P, Dailey Jason I, Ercoli Linda M, Bookheimer Susan Y, Toga Arthur W
Department of Neurology and Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles, California 90095-1769, USA.
Psychosom Med. 2002 May-Jun;64(3):487-92. doi: 10.1097/00006842-200205000-00013.
The objective of this study is to demonstrate the assessment of hippocampal atrophy within a standard brain atlas for persons with age-associated memory impairment (AAMI) compared with cognitively intact elderly.
High-resolution three-dimensional (3D) brain magnetic resonance imaging (MRI) was performed on 20 nondemented persons: 10 had AAMI and 10 were normal elderly. Scans were aligned to a common atlas template to control for errors due to variable brain size and orientation as well as facilitating communication of results across centers. Manual outlining every 1 mm with volumes determined for both the hippocampal head and body was accomplished after coronal resampling perpendicular to the long axis of the hippocampus.
Subject groups were similar in age, sex ratios, and educational achievement. The AAMI group had significantly lower volumes for the right hippocampus and hippocampal head (p =.02) compared with controls.
A growing body of work suggests the right hippocampal head as an early site of atrophy in early memory impairment. Subtle atrophic changes are detectable within a common atlas template allowing imaging assessment across centers.
本研究的目的是在标准脑图谱内，对患有年龄相关性记忆障碍（AAMI）的人与认知功能正常的老年人的海马萎缩情况进行评估，并进行比较。
对20名非痴呆患者进行了高分辨率三维（3D）脑磁共振成像（MRI）检查：其中10名患有AAMI，10名是正常老年人。扫描图像与一个通用的图谱模板对齐，以控制因脑大小和方向不同而产生的误差，并便于跨中心交流结果。在垂直于海马长轴的冠状面重采样后，手动每隔1毫米勾勒出海马头部和体部的轮廓，并确定其体积。
两组受试者在年龄、性别比例和教育程度方面相似。与对照组相比，AAMI组右侧海马和海马头部的体积明显更小（p = 0.02）。
越来越多的研究表明，右侧海马头部是早期记忆障碍中海马萎缩的早期部位。在通用图谱模板内可检测到细微的萎缩变化，从而实现跨中心的影像学评估。
