Babb S M, Wald L L, Cohen B M, Villafuerte R A, Gruber S A, Yurgelun-Todd D A, Renshaw P F
Consolidated Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.
Psychopharmacology (Berl). 2002 May;161(3):248-54. doi: 10.1007/s00213-002-1045-y. Epub 2002 Mar 22.
Phosphatidylcholine (PtdCho) in brain cell membranes decreases with age. Evidence from both animal and in vitro studies indicates that CDP-choline (citicoline) administration may increase phosphatidylcholine (PtdCho) synthesis and might reverse PtdCho loss.
We investigated whether oral citicoline can increase PtdCho synthesis in the brains of older subjects by measuring levels of phosphorus-containing metabolites using proton-decoupled phosphorus magnetic resonance spectroscopy ((31)P-MRS) before and after citicoline treatment.
All subjects took 500 mg citicoline once orally each day for 6 weeks, then took either citicoline or placebo once orally per day for a second 6-week period. Subjects underwent a (31)P-MRS scan at baseline and following 6 and 12 weeks of treatment.
Treatment with citicoline for 6 weeks was associated with a 7.3% increase from baseline levels in brain phosphodiesters ( P=0.008), including an 11.6% increase in glycerophosphoethanolamine ( P=0.002) and a 5.1% increase in glycerophosphocholine ( P=0.137). Subjects who continued to take citicoline for the second 6-week period did not show significant additional increases in the levels of these metabolites. No changes were seen in other phosphorus-containing metabolites. There was a correlation between improvement on the California Verbal Learning Test and increase in phosphodiesters.
The increases in phosphodiesters seen in this study indicate that phospholipid synthesis and turnover were stimulated by 6 weeks of oral citicoline. These results in humans support previous in vitro and animal studies and suggest that the administration of oral citicoline may be of use in reversing age-related changes in the brain.
随着年龄增长，脑细胞膜中的磷脂酰胆碱（PtdCho）会减少。动物和体外研究的证据表明，给予胞磷胆碱（西地那非）可能会增加磷脂酰胆碱（PtdCho）的合成，并可能逆转PtdCho的损失。
我们通过在胞磷胆碱治疗前后使用质子去耦磷磁共振波谱（（31）P-MRS）测量含磷代谢物的水平，研究口服胞磷胆碱是否能增加老年受试者大脑中PtdCho的合成。
所有受试者每天口服一次500毫克胞磷胆碱，持续6周，然后在第二个6周期间每天口服一次胞磷胆碱或安慰剂。受试者在基线时以及治疗6周和12周后接受（31）P-MRS扫描。
胞磷胆碱治疗6周后，脑磷酸二酯水平比基线水平增加了7.3%（P = 0.008），其中甘油磷酸乙醇胺增加了11.6%（P = 0.002），甘油磷酸胆碱增加了5.1%（P = 0.137）。在第二个6周期间继续服用胞磷胆碱的受试者，这些代谢物的水平没有显著进一步增加。其他含磷代谢物未见变化。加利福尼亚言语学习测试的改善与磷酸二酯的增加之间存在相关性。
本研究中观察到的磷酸二酯增加表明，口服胞磷胆碱6周可刺激磷脂合成和周转。这些人体研究结果支持了先前的体外和动物研究，并表明口服胞磷胆碱可能有助于逆转大脑中与年龄相关的变化。
